Network Flow Model Based Analysis of Mouse Hepatocarcinogenesis
نویسندگان
چکیده
Hepatocellular carcinoma (HCC) is one of the most harmful cancer in the world. The transgenic mouse model of hepatocarcinogenesis was established to decipher the pathological mechanism of HCC. Previous studies found that several transgenes play important roles in transgenic mouse carcinogenesis. However, the detail relationship between transgene and other genes is still unknown. In this paper, we propose a network flow based mathematical model to infer the transgene centering functional network (TCFN), which shows the regulatory effect of transgene to the differentially expressed genes, by integrating genome-wide high-throughput data and protein-protein interaction network. The proposed model was applied to transgenic mouse development study. In particular, tumor progress related TCFN on different development stages was identified. The analysis of dynamic changes of TCFN revealed some important genes highly correlated to the tumor development. The TCFN and the identified genes provide new insights on the mouse HCC pathogenic mechanisms.
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تاریخ انتشار 2010